Some recent projects in the Atwal lab include:
- Genomics of the tumor microenvironment.
We are leveraging the power of next generation RNA sequencing in single
cells to uncover the expression landscape of the evolving tumor
microenvironment in breast cancer. Blog post.
- Profiling the immune repertoire.
We use high throughput single cell genomics to quantitatively
characterize the T cell repertoire in normal donors and patients
and human infertility.
We have shown that some of the genes in the p53
tumor suppressor network are under selection in humans and play a role in the regulation of fertility in
mice and humans.
Algorithms are being developed to study whole-genome expression
heterogeneity and evolution in somatic and tumor cells. Collaboration with Wigler lab.
We are exploring the use of information-theoretic methods in the
analysis of large datasets arising in genomics and neuroscience.
- Kerfuffle: a
web-tool for multi-species gene colocalization analysis, R.
Aboukhalil, B. Fendler, G. S. Atwal. pdf
detection of population-specific linkage disequilibrium using haplotype
entropy in the human genome, H. Mizuno, G. S. Atwal, H.
Wang, A. J. Levine, A. Vazquez, BMC Genetics, 11:27 (2010).
PMCID: PMC2873552. pdf
N. Slonim, G. S. Atwal, G. Tkacik and W. Bialek, Proc Nat
Acad Sci (USA) 102, 18297-18302 (2005). pdf (supp)